2ovn

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{{STRUCTURE_2ovn| PDB=2ovn | SCENE= }}
{{STRUCTURE_2ovn| PDB=2ovn | SCENE= }}
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'''NMR structure of the GCN4 trigger peptide'''
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===NMR structure of the GCN4 trigger peptide===
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==Overview==
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Coiled coils have attracted considerable interest as design templates in a wide range of applications. Successful coiled-coil design strategies therefore require a detailed understanding of coiled-coil folding. One common feature shared by coiled coils is the presence of a short autonomous helical folding unit, termed "trigger sequence," that is indispensable for folding. Detailed knowledge of trigger sequences at the molecular level is thus key to a general understanding of coiled-coil formation. Using a multidisciplinary approach, we identify and characterize here the molecular determinants that specify the helical conformation of the monomeric early folding intermediate of the GCN4 coiled coil. We demonstrate that a network of hydrogen-bonding and electrostatic interactions stabilize the trigger-sequence helix. This network is rearranged in the final dimeric coiled-coil structure, and its destabilization significantly slows down GCN4 leucine zipper folding. Our findings provide a general explanation for the molecular mechanism of coiled-coil formation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17438295 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17438295}}
==About this Structure==
==About this Structure==
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2OVN is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVN OCA].
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2OVN is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVN OCA].
==Reference==
==Reference==
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[[Category: Gcn4]]
[[Category: Gcn4]]
[[Category: Trigger peptide]]
[[Category: Trigger peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:45:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:50:04 2008''

Revision as of 15:50, 28 July 2008

Image:2ovn.png

Template:STRUCTURE 2ovn

NMR structure of the GCN4 trigger peptide

Template:ABSTRACT PUBMED 17438295

About this Structure

2OVN is a Single protein structure. Full experimental information is available from OCA.

Reference

Molecular basis of coiled-coil formation., Steinmetz MO, Jelesarov I, Matousek WM, Honnappa S, Jahnke W, Missimer JH, Frank S, Alexandrescu AT, Kammerer RA, Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7062-7. Epub 2007 Apr 16. PMID:17438295

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