2ovr

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[[Image:2ovr.gif|left|200px]]
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{{STRUCTURE_2ovr| PDB=2ovr | SCENE= }}
{{STRUCTURE_2ovr| PDB=2ovr | SCENE= }}
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'''Structure of the Skp1-Fbw7-CyclinEdegN complex'''
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===Structure of the Skp1-Fbw7-CyclinEdegN complex===
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==Overview==
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The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer. Cyclin E degradation is triggered by multisite phosphorylation, which induces binding to the SCF(Fbw7) ubiquitin ligase complex. Structures of the Skp1-Fbw7 complex bound to cyclin E peptides identify a doubly phosphorylated pThr380/pSer384 cyclin E motif as an optimal, high-affinity degron and a singly phosphorylated pThr62 motif as a low-affinity one. Biochemical data indicate that the closely related yeast SCF(Cdc4) complex recognizes the multisite phosphorylated Sic1 substrate similarly and identify three doubly phosphorylated Sic1 degrons, each capable of high-affinity interactions with two Cdc4 phosphate binding sites. A model that explains the role of multiple cyclin E/Sic1 degrons is provided by the findings that Fbw7 and Cdc4 dimerize, that Fbw7 dimerization enhances the turnover of a weakly associated cyclin E in vivo, and that Cdc4 dimerization increases the rate and processivity of Sic1 ubiquitination in vitro.
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The line below this paragraph, {{ABSTRACT_PUBMED_17434132}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17434132 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17434132}}
==About this Structure==
==About this Structure==
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[[Category: F-box]]
[[Category: F-box]]
[[Category: Wd40 domain]]
[[Category: Wd40 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:45:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:43:49 2008''

Revision as of 03:43, 29 July 2008

Image:2ovr.png

Template:STRUCTURE 2ovr

Structure of the Skp1-Fbw7-CyclinEdegN complex

Template:ABSTRACT PUBMED 17434132

About this Structure

2OVR is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases., Hao B, Oehlmann S, Sowa ME, Harper JW, Pavletich NP, Mol Cell. 2007 Apr 13;26(1):131-43. PMID:17434132

Page seeded by OCA on Tue Jul 29 06:43:49 2008

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