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2ox8

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[[Image:2ox8.jpg|left|200px]]
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{{Seed}}
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[[Image:2ox8.png|left|200px]]
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{{STRUCTURE_2ox8| PDB=2ox8 | SCENE= }}
{{STRUCTURE_2ox8| PDB=2ox8 | SCENE= }}
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'''Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.'''
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===Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.===
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==Overview==
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The scavenger receptor C-type lectin (SRCL) is unique in the family of class A scavenger receptors, because in addition to binding sites for oxidized lipoproteins it also contains a C-type carbohydrate-recognition domain (CRD) that interacts with specific glycans. Both human and mouse SRCL are highly specific for the Lewis(x) trisaccharide, which is commonly found on the surfaces of leukocytes and some tumor cells. Structural analysis of the CRD of mouse SRCL in complex with Lewis(x) and mutagenesis show the basis for this specificity. The interaction between mouse SRCL and Lewis(x) is analogous to the way that selectins and DC-SIGN bind to related fucosylated glycans, but the mechanism of the interaction is novel, because it is based on a primary galactose-binding site similar to the binding site in the asialoglycoprotein receptor. Crystals of the human receptor lacking bound calcium ions reveal an alternative conformation in which a glycan ligand would be released during receptor-mediated endocytosis.
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The line below this paragraph, {{ABSTRACT_PUBMED_17420244}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17420244 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17420244}}
==About this Structure==
==About this Structure==
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[[Category: Weis, W I.]]
[[Category: Weis, W I.]]
[[Category: C-type lectin]]
[[Category: C-type lectin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:51:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:25:22 2008''

Revision as of 23:25, 27 July 2008

Image:2ox8.png

Template:STRUCTURE 2ox8

Human Scavenger Receptor C-type Lectin carbohydrate-recognition domain.

Template:ABSTRACT PUBMED 17420244

About this Structure

2OX8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism., Feinberg H, Taylor ME, Weis WI, J Biol Chem. 2007 Jun 8;282(23):17250-8. Epub 2007 Apr 9. PMID:17420244

Page seeded by OCA on Mon Jul 28 02:25:22 2008

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