2oxm

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[[Image:2oxm.gif|left|200px]]
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{{STRUCTURE_2oxm| PDB=2oxm | SCENE= }}
{{STRUCTURE_2oxm| PDB=2oxm | SCENE= }}
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'''Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping'''
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===Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping===
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==Overview==
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The enzyme uracil DNA glycosylase (UNG) excises unwanted uracil bases in the genome using an extrahelical base recognition mechanism. Efficient removal of uracil is essential for prevention of C-to-T transition mutations arising from cytosine deamination, cytotoxic U*A pairs arising from incorporation of dUTP in DNA, and for increasing immunoglobulin gene diversity during the acquired immune response. A central event in all of these UNG-mediated processes is the singling out of rare U*A or U*G base pairs in a background of approximately 10(9) T*A or C*G base pairs in the human genome. Here we establish for the human and Escherichia coli enzymes that discrimination of thymine and uracil is initiated by thermally induced opening of T*A and U*A base pairs and not by active participation of the enzyme. Thus, base-pair dynamics has a critical role in the genome-wide search for uracil, and may be involved in initial damage recognition by other DNA repair glycosylases.
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(as it appears on PubMed at http://www.pubmed.gov), where 17704764 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17704764}}
==About this Structure==
==About this Structure==
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[[Category: Ung2]]
[[Category: Ung2]]
[[Category: Uracil dna glycosylase]]
[[Category: Uracil dna glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:53:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:57:12 2008''

Revision as of 13:57, 27 July 2008

Image:2oxm.png

Template:STRUCTURE 2oxm

Crystal structure of a UNG2/modified DNA complex that represent a stabilized short-lived extrahelical state in ezymatic DNA base flipping

Template:ABSTRACT PUBMED 17704764

About this Structure

2OXM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Enzymatic capture of an extrahelical thymine in the search for uracil in DNA., Parker JB, Bianchet MA, Krosky DJ, Friedman JI, Amzel LM, Stivers JT, Nature. 2007 Sep 27;449(7161):433-7. Epub 2007 Aug 19. PMID:17704764

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