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2oza

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{{STRUCTURE_2oza| PDB=2oza | SCENE= }}
{{STRUCTURE_2oza| PDB=2oza | SCENE= }}
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'''Structure of p38alpha complex'''
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===Structure of p38alpha complex===
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==Overview==
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p38 MAPK and MAPK-activated protein kinase 2 (MK2) are key components of signaling pathways leading to many cellular responses, notably the proinflammatory cytokine production. The physical association of p38alpha isoform and MK2 is believed to be physiologically important for this signaling. We report the 2.7-A resolution crystal structure of the unphosphorylated complex between p38alpha and MK2. These protein kinases bind "head-to-head," present their respective active sites on approximately the same side of the heterodimer, and form extensive intermolecular interactions. Among these interactions, the MK2 Ile-366-Ala-390, which includes the bipartite nuclear localization signal, binds to the p38alpha-docking region. This binding supports the involvement of noncatalytic regions to the tight binding of the MK2:p38alpha binary assembly. The MK2 residues 345-365, containing the nuclear export signal, block access to the p38alpha active site. Some regulatory phosphorylation regions of both protein kinases engage in multiple interactions with one another in this complex. This structure gives new insights into the regulation of the protein kinases p38alpha and MK2, aids in the better understanding of their known cellular and biochemical studies, and provides a basis for understanding other regulatory protein-protein interactions involving signal transduction proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17395714 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17395714}}
==About this Structure==
==About this Structure==
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[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
[[Category: Serine/threonine kinase]]
[[Category: Serine/threonine kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:59:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:54:50 2008''

Revision as of 19:54, 27 July 2008

Image:2oza.png

Template:STRUCTURE 2oza

Structure of p38alpha complex

Template:ABSTRACT PUBMED 17395714

About this Structure

2OZA is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Molecular basis of MAPK-activated protein kinase 2:p38 assembly., White A, Pargellis CA, Studts JM, Werneburg BG, Farmer BT 2nd, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6353-8. Epub 2007 Mar 29. PMID:17395714

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