2p03

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{{STRUCTURE_2p03| PDB=2p03 | SCENE= }}
{{STRUCTURE_2p03| PDB=2p03 | SCENE= }}
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'''The structure of receptor-associated protein(RAP)'''
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===The structure of receptor-associated protein(RAP)===
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==Overview==
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The receptor-associated protein (RAP) is a molecular chaperone that binds tightly to certain newly synthesized LDL receptor family members in the endoplasmic reticulum (ER) and facilitates their delivery to the Golgi. We have adopted a divide-and-conquer strategy to solve the structures of the individual domains of RAP using NMR spectroscopy. We present here the newly determined structure of domain 2. Based on this structure and the structures of domains 1 and 3, which were solved previously, we utilized experimental small-angle neutron scattering (SANS) data and a novel simulated annealing protocol to characterize the overall structure of RAP. The results reveal that RAP adopts a unique structural architecture consisting of three independent three-helix bundles that are connected by long and flexible linkers. The flexible linkers and the quasi-repetitive structural architecture may allow RAP to adopt various possible conformations when interacting with the LDL receptors, which are also made of repetitive substructure units.
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(as it appears on PubMed at http://www.pubmed.gov), where 17656581 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17656581}}
==About this Structure==
==About this Structure==
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2P03 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P03 OCA].
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2P03 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P03 OCA].
==Reference==
==Reference==
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[[Category: Rap]]
[[Category: Rap]]
[[Category: Receptor-associated protein]]
[[Category: Receptor-associated protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:02:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:05:47 2008''

Revision as of 16:05, 28 July 2008

Image:2p03.png

Template:STRUCTURE 2p03

The structure of receptor-associated protein(RAP)

Template:ABSTRACT PUBMED 17656581

About this Structure

2P03 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure of receptor-associated protein (RAP)., Lee D, Walsh JD, Migliorini M, Yu P, Cai T, Schwieters CD, Krueger S, Strickland DK, Wang YX, Protein Sci. 2007 Aug;16(8):1628-40. PMID:17656581

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