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2p2l

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{{STRUCTURE_2p2l| PDB=2p2l | SCENE= }}
{{STRUCTURE_2p2l| PDB=2p2l | SCENE= }}
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'''Rac1-GDP-Zinc Complex'''
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===Rac1-GDP-Zinc Complex===
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==Overview==
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The Rho family of small GTPases represent well characterized signaling molecules that regulate many cellular functions such as actin cytoskeletal arrangement and the cell cycle by acting as molecular switches. A Rac1-GDP-Zn complex has been crystallized in space group P3(2)21 and its crystal structure has been solved at 1.9 A resolution. These trigonal crystals reveal the unexpected ability of Rac1 to coordinate Zn atoms in a tetrahedral fashion by use of its biologically relevant switch I and switch II regions. Upon coordination of zinc, the switch I region is stabilized in the GDP-bound conformation and contributes to a Rac1 trimer in the asymmetric unit. Zinc coordination causes switch II to adopt a novel conformation with a symmetry-related molecule. Additionally, zinc was found to displace magnesium from its octahedral coordination at switch I, although GDP binding remained stable. This structure represents the first reported Rac1-GDP-Zn complex, which further underscores the conformational flexibility and versatility of the small GTPase switch regions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17452788 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17452788}}
==About this Structure==
==About this Structure==
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[[Category: Rho family gtpase]]
[[Category: Rho family gtpase]]
[[Category: Zinc]]
[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:12:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:17:55 2008''

Revision as of 01:17, 28 July 2008

Image:2p2l.png

Template:STRUCTURE 2p2l

Rac1-GDP-Zinc Complex

Template:ABSTRACT PUBMED 17452788

About this Structure

2P2L is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium., Prehna G, Stebbins CE, Acta Crystallogr D Biol Crystallogr. 2007 May;63(Pt 5):628-35. Epub 2007, Apr 21. PMID:17452788

Page seeded by OCA on Mon Jul 28 04:17:55 2008

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