2p59

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[[Image:2p59.jpg|left|200px]]
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{{STRUCTURE_2p59| PDB=2p59 | SCENE= }}
{{STRUCTURE_2p59| PDB=2p59 | SCENE= }}
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'''Crystal Structure of Hepatitis C Virus NS3.4A protease'''
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===Crystal Structure of Hepatitis C Virus NS3.4A protease===
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==Overview==
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Reversible tetrapeptide-based compounds have been shown to effectively inhibit the hepatitis C virus NS3.4A protease. Inhibition of viral replicon RNA production in Huh-7 cells has also been demonstrated. We show herein that the inclusion of hydrogen bond donors on the P4 capping group of tetrapeptide-based inhibitors result in increased binding potency to the NS3.4A protease. The capping groups also impart significant effects on the pharmacokinetic profile of these inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 17482818 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17482818}}
==About this Structure==
==About this Structure==
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[[Category: Hcv protease]]
[[Category: Hcv protease]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:23:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:11:04 2008''

Revision as of 01:11, 28 July 2008

Image:2p59.png

Template:STRUCTURE 2p59

Crystal Structure of Hepatitis C Virus NS3.4A protease

Template:ABSTRACT PUBMED 17482818

About this Structure

2P59 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:17482818

Page seeded by OCA on Mon Jul 28 04:11:04 2008

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