2p83

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{{STRUCTURE_2p83| PDB=2p83 | SCENE= }}
{{STRUCTURE_2p83| PDB=2p83 | SCENE= }}
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'''Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1'''
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===Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1===
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==Overview==
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The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.
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The line below this paragraph, {{ABSTRACT_PUBMED_17434734}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17434734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17434734}}
==About this Structure==
==About this Structure==
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[[Category: Tomasselli, A G.]]
[[Category: Tomasselli, A G.]]
[[Category: Protein-inhibitor complex]]
[[Category: Protein-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:34:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:57:55 2008''

Revision as of 11:58, 27 July 2008

Template:STRUCTURE 2p83

Potent and selective isophthalamide S2 hydroxyethylamine inhibitor of BACE1

Template:ABSTRACT PUBMED 17434734

About this Structure

2P83 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1., Kortum SW, Benson TE, Bienkowski MJ, Emmons TL, Prince DB, Paddock DJ, Tomasselli AG, Moon JB, LaBorde A, TenBrink RE, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3378-83. Epub 2007 Apr 3. PMID:17434734

Page seeded by OCA on Sun Jul 27 14:57:55 2008

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