2p8v

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[[Image:2p8v.jpg|left|200px]]
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{{Seed}}
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[[Image:2p8v.png|left|200px]]
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{{STRUCTURE_2p8v| PDB=2p8v | SCENE= }}
{{STRUCTURE_2p8v| PDB=2p8v | SCENE= }}
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'''Crystal structure of human Homer3 EVH1 domain'''
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===Crystal structure of human Homer3 EVH1 domain===
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==Overview==
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T cell receptor (TCR) and costimulatory receptor (CD28) signals cooperate in activating T cells, although understanding of how these pathways are themselves regulated is incomplete. We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation. This is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin. Homer-NFAT binding was also antagonized by active serine-threonine kinase AKT, thereby enhancing TCR signaling via calcineurin-dependent dephosphorylation of NFAT. This corresponded with changes in cytokine expression and an increase in effector-memory T cell populations in Homer-deficient mice, which also developed autoimmune-like pathology. These results demonstrate a further means by which costimulatory signals are regulated to control self-reactivity.
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(as it appears on PubMed at http://www.pubmed.gov), where 18218901 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18218901}}
==About this Structure==
==About this Structure==
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[[Category: Homer3]]
[[Category: Homer3]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:37:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:48:34 2008''

Revision as of 05:48, 29 July 2008

Image:2p8v.png

Template:STRUCTURE 2p8v

Crystal structure of human Homer3 EVH1 domain

Template:ABSTRACT PUBMED 18218901

About this Structure

2P8V is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins., Huang GN, Huso DL, Bouyain S, Tu J, McCorkell KA, May MJ, Zhu Y, Lutz M, Collins S, Dehoff M, Kang S, Whartenby K, Powell J, Leahy D, Worley PF, Science. 2008 Jan 25;319(5862):476-81. PMID:18218901

Page seeded by OCA on Tue Jul 29 08:48:34 2008

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