2p9h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2p9h.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2p9h.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2p9h| PDB=2p9h | SCENE= }}
{{STRUCTURE_2p9h| PDB=2p9h | SCENE= }}
-
'''High resolution structure of the Lactose Repressor bound to IPTG'''
+
===High resolution structure of the Lactose Repressor bound to IPTG===
-
==Overview==
+
<!--
-
The lac operon is a model system for understanding how effector molecules regulate transcription and are necessary for allosteric transitions. The crystal structures of the lac repressor bound to inducer and anti-inducer molecules provide a model for how these small molecules can modulate repressor function. The structures of the apo repressor and the repressor bound to effector molecules are compared in atomic detail. All effectors examined here bind to the repressor in the same location and are anchored to the repressor through hydrogen bonds to several hydroxyl groups of the sugar ring. Inducer molecules form a more extensive hydrogen-bonding network compared to anti-inducers and neutral effector molecules. The structures of these effector molecules suggest that the O6 hydroxyl on the galactoside is essential for establishing a water-mediated hydrogen bonding network that bridges the N-terminal and C-terminal sub-domains. The altered hydrogen bonding can account in part for the different structural conformations of the repressor, and is vital for the allosteric transition.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17543986}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17543986 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17543986}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Gene regulation]]
[[Category: Gene regulation]]
[[Category: Lac repressor]]
[[Category: Lac repressor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:40:03 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:06:13 2008''

Revision as of 01:06, 28 July 2008

Image:2p9h.png

Template:STRUCTURE 2p9h

High resolution structure of the Lactose Repressor bound to IPTG

Template:ABSTRACT PUBMED 17543986

About this Structure

2P9H is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural analysis of lac repressor bound to allosteric effectors., Daber R, Stayrook S, Rosenberg A, Lewis M, J Mol Biol. 2007 Jul 20;370(4):609-19. Epub 2007 Apr 19. PMID:17543986

Page seeded by OCA on Mon Jul 28 04:06:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p9h"
Personal tools