2pbi

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[[Image:2pbi.jpg|left|200px]]
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{{STRUCTURE_2pbi| PDB=2pbi | SCENE= }}
{{STRUCTURE_2pbi| PDB=2pbi | SCENE= }}
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'''The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure'''
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===The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure===
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==Overview==
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Regulators of G-protein signaling (RGS) proteins enhance the intrinsic GTPase activity of G protein alpha (Galpha) subunits and are vital for proper signaling kinetics downstream of G protein-coupled receptors (GPCRs). R7 subfamily RGS proteins specifically and obligately dimerize with the atypical G protein beta5 (Gbeta5) subunit through an internal G protein gamma (Ggamma)-subunit-like (GGL) domain. Here we present the 1.95-A crystal structure of the Gbeta5-RGS9 complex, which is essential for normal visual and neuronal signal transduction. This structure reveals a canonical RGS domain that is functionally integrated within a molecular complex that is poised for integration of multiple steps during G-protein activation and deactivation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18204463 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18204463}}
==About this Structure==
==About this Structure==
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[[Category: Rgs domain]]
[[Category: Rgs domain]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:46:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:02:20 2008''

Revision as of 17:02, 28 July 2008

Image:2pbi.png

Template:STRUCTURE 2pbi

The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure

Template:ABSTRACT PUBMED 18204463

About this Structure

2PBI is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the multifunctional Gbeta5-RGS9 complex., Cheever ML, Snyder JT, Gershburg S, Siderovski DP, Harden TK, Sondek J, Nat Struct Mol Biol. 2008 Feb;15(2):155-62. Epub 2008 Jan 20. PMID:18204463

Page seeded by OCA on Mon Jul 28 20:02:20 2008

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