2pe6

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{{STRUCTURE_2pe6| PDB=2pe6 | SCENE= }}
{{STRUCTURE_2pe6| PDB=2pe6 | SCENE= }}
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'''Non-covalent complex between human SUMO-1 and human Ubc9'''
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===Non-covalent complex between human SUMO-1 and human Ubc9===
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==Overview==
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The SUMO E2 Ubc9 serves as a lynchpin in the SUMO conjugation pathway, interacting with the SUMO E1 during activation, with thioester linked SUMO after E1 transfer and with the substrate and SUMO E3 ligases during conjugation. Here, we describe the structure determination of a non-covalent complex between human Ubc9 and SUMO-1 at 2.4 A resolution. Non-covalent interactions between Ubc9 and SUMO are conserved in human and yeast insomuch as human Ubc9 interacts with each of the human SUMO isoforms, and yeast Ubc9 interacts with Smt3, the yeast SUMO ortholog. Structural comparisons reveal similarities to several other non-covalent complexes in the ubiquitin pathway, suggesting that the non-covalent Ubc9-SUMO interface may be important for poly-SUMO chain formation, for E2 recruitment to SUMO conjugated substrates, or for mediating E2 interactions with either E1 or E3 ligases. Biochemical analysis suggests that this surface is less important for E1 activation or di-SUMO-2 formation, but more important for E3 interactions and for poly-SUMO chain formation when the chain exceeds more than two SUMO proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17466333 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17466333}}
==About this Structure==
==About this Structure==
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[[Category: Ubc9]]
[[Category: Ubc9]]
[[Category: Ubiquitin-like]]
[[Category: Ubiquitin-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:56:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:50:59 2008''

Revision as of 16:51, 28 July 2008

Image:2pe6.png

Template:STRUCTURE 2pe6

Non-covalent complex between human SUMO-1 and human Ubc9

Template:ABSTRACT PUBMED 17466333

About this Structure

2PE6 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction., Capili AD, Lima CD, J Mol Biol. 2007 Jun 8;369(3):608-18. Epub 2007 Apr 6. PMID:17466333

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