1kcu
From Proteopedia
(New page: 200px<br /> <applet load="1kcu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kcu, resolution 2.20Å" /> '''CRYSTAL STRUCTURE O...) |
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caption="1kcu, resolution 2.20Å" /> | caption="1kcu, resolution 2.20Å" /> | ||
'''CRYSTAL STRUCTURE OF ANTIBODY PC287'''<br /> | '''CRYSTAL STRUCTURE OF ANTIBODY PC287'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1KCU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http:// | + | 1KCU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KCU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: anti-peptide antibody]] | [[Category: anti-peptide antibody]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:12:36 2008'' |
Revision as of 14:12, 15 February 2008
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CRYSTAL STRUCTURE OF ANTIBODY PC287
Overview
Crystal structures of distinct mAbs that recognize a common epitope of a, peptide Ag have been determined and analyzed in the unbound and bound, forms. These Abs display dissimilar binding site structures in the absence, of the Ag. The dissimilarity is primarily expressed in the conformations, of complementarity-determining region H3, which is responsible for, defining the epitope specificity. Interestingly, however, the three Abs, exhibit similar complementarity-determining region conformations in the Ag, binding site while recognizing the common epitope, indicating that, different pathways of binding are used for Ag recognition. The epitope, also exhibits conformational similarity when bound to each of these Abs, although the peptide Ag was otherwise flexible. The observed, conformational convergence in the epitope and the Ag binding site was, facilitated by the plasticity in the nature of interactions.
About this Structure
1KCU is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response., Nair DT, Singh K, Siddiqui Z, Nayak BP, Rao KV, Salunke DM, J Immunol. 2002 Mar 1;168(5):2371-82. PMID:11859128
Page seeded by OCA on Fri Feb 15 16:12:36 2008
