2pl4

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{{STRUCTURE_2pl4| PDB=2pl4 | SCENE= }}
{{STRUCTURE_2pl4| PDB=2pl4 | SCENE= }}
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'''D-(GGTATACC) under 0.55 GPa hydrostatic pressure'''
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===D-(GGTATACC) under 0.55 GPa hydrostatic pressure===
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==Overview==
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The behaviour of the d(GGTATACC) oligonucleotide has been investigated by X-ray crystallography at 295 K in the range from ambient pressure to 2 GPa (approximately 20,000 atm). Four 3D-structures of the A-DNA form (at ambient pressure, 0.55, 1.09 and 1.39 GPa) were refined at 1.60 or 1.65 A resolution. In addition to the diffraction pattern of the A-form, the broad meridional streaks previously explained by occluded B-DNA octamers within the channels of the crystalline A-form matrix were observed up to at least 2 GPa. This work highlights an important property of nucleic acids, their capability to withstand very high pressures, while keeping in such conditions a nearly invariant geometry of base pairs that store and carry genetic information. The double-helix base-paired architecture behaves as a molecular spring, which makes it especially adapted to very harsh conditions. These features may have contributed to the emergence of a RNA World at prebiotic stage.
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(as it appears on PubMed at http://www.pubmed.gov), where 17617642 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17617642}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642]
Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17617642 17617642]
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Coexistence of A- and B-form DNA in a single crystal lattice., Doucet J, Benoit JP, Cruse WB, Prange T, Kennard O, Nature. 1989 Jan 12;337(6203):190-2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2911354 2911354]
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High-pressure protein crystallography (HPPX): instrumentation, methodology and results on lysozyme crystals., Fourme R, Kahn R, Mezouar M, Girard E, Hoerentrup C, Prange T, Ascone I, J Synchrotron Radiat. 2001 Sep 1;8(Pt 5):1149-56. Epub 2001 Aug 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11524565 11524565]
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High pressure macromolecular crystallography: the 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly., Colloc'h N, Girard E, Dhaussy AC, Kahn R, Ascone I, Mezouar M, Fourme R, Biochim Biophys Acta. 2006 Mar;1764(3):391-7. Epub 2006 Jan 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16478683 16478683]
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Crystal structure of hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres., Kundrot CE, Richards FM, J Mol Biol. 1987 Jan 5;193(1):157-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/3586017 3586017]
[[Category: Fourme, R.]]
[[Category: Fourme, R.]]
[[Category: Girard, E.]]
[[Category: Girard, E.]]
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[[Category: Crystal stucture]]
[[Category: Crystal stucture]]
[[Category: High-pressure]]
[[Category: High-pressure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:28:21 2008''

Revision as of 10:28, 29 July 2008

Image:2pl4.png

Template:STRUCTURE 2pl4

D-(GGTATACC) under 0.55 GPa hydrostatic pressure

Template:ABSTRACT PUBMED 17617642

About this Structure

Full crystallographic information is available from OCA.

Reference

Adaptation of the base-paired double-helix molecular architecture to extreme pressure., Girard E, Prange T, Dhaussy AC, Migianu-Griffoni E, Lecouvey M, Chervin JC, Mezouar M, Kahn R, Fourme R, Nucleic Acids Res. 2007;35(14):4800-8. Epub 2007 Jul 7. PMID:17617642

Coexistence of A- and B-form DNA in a single crystal lattice., Doucet J, Benoit JP, Cruse WB, Prange T, Kennard O, Nature. 1989 Jan 12;337(6203):190-2. PMID:2911354

High-pressure protein crystallography (HPPX): instrumentation, methodology and results on lysozyme crystals., Fourme R, Kahn R, Mezouar M, Girard E, Hoerentrup C, Prange T, Ascone I, J Synchrotron Radiat. 2001 Sep 1;8(Pt 5):1149-56. Epub 2001 Aug 28. PMID:11524565

High pressure macromolecular crystallography: the 140-MPa crystal structure at 2.3 A resolution of urate oxidase, a 135-kDa tetrameric assembly., Colloc'h N, Girard E, Dhaussy AC, Kahn R, Ascone I, Mezouar M, Fourme R, Biochim Biophys Acta. 2006 Mar;1764(3):391-7. Epub 2006 Jan 26. PMID:16478683

Crystal structure of hen egg-white lysozyme at a hydrostatic pressure of 1000 atmospheres., Kundrot CE, Richards FM, J Mol Biol. 1987 Jan 5;193(1):157-70. PMID:3586017

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