2pmw

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[[Image:2pmw.jpg|left|200px]]
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{{STRUCTURE_2pmw| PDB=2pmw | SCENE= }}
{{STRUCTURE_2pmw| PDB=2pmw | SCENE= }}
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'''The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)'''
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===The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)===
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==Overview==
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Proprotein convertase subtilisin kexin type 9 (PCSK9) has been shown to be involved in the regulation of extracellular levels of the low-density lipoprotien receptor (LDLR). Although PCSK9 is a subtilase, it has not been shown to degrade the LDLR, and its LDLR-lowering mechanism remains uncertain. Here we report the crystal structure of human PCSK9 at 2.3 A resolution. PCSK9 has subtilisin-like pro- and catalytic domains, and the stable interaction between these domains prevents access to PCSK9's catalytic site. The C-terminal domain of PCSK9 has a novel protein fold and may mediate protein-protein interactions. The structure of PCSK9 provides insight into its biochemical characteristics and biological function.
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(as it appears on PubMed at http://www.pubmed.gov), where 17502100 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17502100}}
==About this Structure==
==About this Structure==
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[[Category: Protease]]
[[Category: Protease]]
[[Category: Subtilisin]]
[[Category: Subtilisin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:26:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:50:01 2008''

Revision as of 06:50, 28 July 2008

Image:2pmw.png

Template:STRUCTURE 2pmw

The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)

Template:ABSTRACT PUBMED 17502100

About this Structure

2PMW is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol., Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP, Structure. 2007 May;15(5):545-52. PMID:17502100

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