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2pnh

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{{STRUCTURE_2pnh| PDB=2pnh | SCENE= }}
{{STRUCTURE_2pnh| PDB=2pnh | SCENE= }}
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'''Escherichia coli PriB E39A variant'''
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===Escherichia coli PriB E39A variant===
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==Overview==
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Collapsed DNA replication forks must be reactivated through origin-independent reloading of the replication machinery (replisome) to ensure complete duplication of cellular genomes. In E. coli, the PriA-dependent pathway is the major replication restart mechanism and requires primosome proteins PriA, PriB, and DnaT for replisome reloading. However, the molecular mechanisms that regulate origin-independent replisome loading are not fully understood. Here, we demonstrate that assembly of primosome protein complexes represents a key regulatory mechanism, as inherently weak PriA-PriB and PriB-DnaT interactions are strongly stimulated by single-stranded DNA. Furthermore, the binding site on PriB for single-stranded DNA partially overlaps the binding sites for PriA and DnaT, suggesting a dynamic primosome assembly process in which single-stranded DNA is handed off from one primosome protein to another as a repaired replication fork is reactivated. This model helps explain how origin-independent initiation of DNA replication is restricted to repaired replication forks, preventing overreplication of the genome.
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{{ABSTRACT_PUBMED_17588514}}
==About this Structure==
==About this Structure==
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[[Category: Dna binding protein]]
[[Category: Dna binding protein]]
[[Category: Ob fold]]
[[Category: Ob fold]]
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Revision as of 11:33, 27 July 2008

Image:2pnh.png

Template:STRUCTURE 2pnh

Escherichia coli PriB E39A variant

Template:ABSTRACT PUBMED 17588514

About this Structure

2PNH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

A hand-off mechanism for primosome assembly in replication restart., Lopper M, Boonsombat R, Sandler SJ, Keck JL, Mol Cell. 2007 Jun 22;26(6):781-93. PMID:17588514

Page seeded by OCA on Sun Jul 27 14:33:11 2008

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