2pqs

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{{STRUCTURE_2pqs| PDB=2pqs | SCENE= }}
{{STRUCTURE_2pqs| PDB=2pqs | SCENE= }}
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'''Crystal Structure of the Bovine Lactadherin C2 Domain'''
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===Crystal Structure of the Bovine Lactadherin C2 Domain===
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==Overview==
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Lactadherin, a glycoprotein secreted by a variety of cell types, contains two EGF domains and two C domains with sequence homology to the C domains of blood coagulation proteins factor V and factor VIII. Like these proteins, lactadherin binds to phosphatidylserine (PS)-containing membranes with high affinity. We determined the crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A. The lactadherin C2 structure is similar to the C2 domains of factors V and VIII (rmsd of C(alpha) atoms of 0.9 A and 1.2 A, and sequence identities of 43% and 38%, respectively). The lactadherin C2 domain has a discoidin-like fold containing two beta-sheets of five and three antiparallel beta-strands packed against one another. The N and C termini are linked by a disulfide bridge between Cys1 and Cys158. One beta-turn and two loops containing solvent-exposed hydrophobic residues extend from the C2 domain beta-sandwich core. In analogy with the C2 domains of factors V and VIII, some or all of these solvent-exposed hydrophobic residues, Trp26, Leu28, Phe31, and Phe81, likely participate in membrane binding. The C2 domain of lactadherin may serve as a marker of cell surface phosphatidylserine exposure and may have potential as a unique anti-thrombotic agent.
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(as it appears on PubMed at http://www.pubmed.gov), where 17583728 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17583728}}
==About this Structure==
==About this Structure==
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[[Category: Lactadherin]]
[[Category: Lactadherin]]
[[Category: Membrane binding]]
[[Category: Membrane binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:38:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:22:10 2008''

Revision as of 11:22, 27 July 2008

Image:2pqs.png

Template:STRUCTURE 2pqs

Crystal Structure of the Bovine Lactadherin C2 Domain

Template:ABSTRACT PUBMED 17583728

About this Structure

2PQS is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII., Lin L, Huai Q, Huang M, Furie B, Furie BC, J Mol Biol. 2007 Aug 17;371(3):717-24. Epub 2007 May 25. PMID:17583728

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