2pr3

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{{STRUCTURE_2pr3| PDB=2pr3 | SCENE= }}
{{STRUCTURE_2pr3| PDB=2pr3 | SCENE= }}
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'''Factor XA inhibitor'''
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===Factor XA inhibitor===
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==Overview==
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A novel series of pyrrolidine-1,2-dicarboxamides was discovered as factor Xa inhibitors using structure-based drug design. This series consisted of a neutral 4-chlorophenylurea P1, a biphenylsulfonamide P4 and a D-proline scaffold (1, IC(50) = 18 nM). Optimization of the initial hit resulted in an orally bioavailable, subnanomolar inhibitor of factor Xa (13, IC(50) = 0.38 nM), which was shown to be efficacious in a canine electrolytic model of thrombosis with minimal bleeding.
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{{ABSTRACT_PUBMED_17581239}}
==Disease==
==Disease==
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[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Fxa coagulation factor inhibitor]]
[[Category: Fxa coagulation factor inhibitor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:39:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:12:58 2008''

Revision as of 12:13, 28 July 2008

Image:2pr3.png

Template:STRUCTURE 2pr3

Contents

Factor XA inhibitor

Template:ABSTRACT PUBMED 17581239

Disease

Known disease associated with this structure: Factor X deficiency OMIM:[227600]

About this Structure

2PR3 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure-based drug design of pyrrolidine-1, 2-dicarboxamides as a novel series of orally bioavailable factor Xa inhibitors., Van Huis CA, Bigge CF, Casimiro-Garcia A, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Narasimhan LS, Schaum RP, Zhang E, Bryant JW, Haarer S, Janiczek N, Leadley RJ Jr, McClanahan T, Thomas Peterson J, Welch KM, Edmunds JJ, Chem Biol Drug Des. 2007 Jun;69(6):444-50. PMID:17581239

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