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2pt2

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{{STRUCTURE_2pt2| PDB=2pt2 | SCENE= }}
{{STRUCTURE_2pt2| PDB=2pt2 | SCENE= }}
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'''Structure of FutA1 with Iron(II)'''
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===Structure of FutA1 with Iron(II)===
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==Overview==
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Cyanobacteria account for a significant percentage of aquatic primary productivity even in areas where the concentrations of essential micronutrients are extremely low. To better understand the mechanism of iron selectivity and transport, the structure of the solute binding domain of an ATP binding cassette iron transporter, FutA1, was determined in the presence and absence of iron. The iron ion is bound within the "C-clamp" structure via four tyrosine and one histidine residues. There are extensive interactions between these ligating residues and the rest of the protein such that the conformations of the side chains remain relatively unchanged as the iron is released by the opening of the metal binding cleft. This is in stark contrast to the zinc-binding protein, ZnuA, where the domains of the metal-binding protein remain relatively fixed, whereas the ligating residues rotate out of the binding pocket upon metal release. The rotation of the domains in FutA1 is facilitated by two flexible beta-strands running along the back of the protein that act like a hinge during domain motion. This motion may require relatively little energy since total contact area between the domains is the same whether the protein is in the open or closed conformation. Consistent with the pH dependence of iron binding, the main trigger for iron release is likely the histidine in the iron-binding site. Finally, neither FutA1 nor FutA2 binds iron as a siderophore complex or in the presence of anions, and both preferentially bind ferrous over ferric ions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17626019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17626019}}
==About this Structure==
==About this Structure==
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[[Category: Periplasmic binding protein]]
[[Category: Periplasmic binding protein]]
[[Category: Solute-binding protein]]
[[Category: Solute-binding protein]]
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Revision as of 07:43, 28 July 2008

Image:2pt2.png

Template:STRUCTURE 2pt2

Structure of FutA1 with Iron(II)

Template:ABSTRACT PUBMED 17626019

About this Structure

2PT2 is a Single protein structure of sequence from Synechocystis sp.. Full crystallographic information is available from OCA.

Reference

The structure of the iron-binding protein, FutA1, from Synechocystis 6803., Koropatkin N, Randich AM, Bhattacharyya-Pakrasi M, Pakrasi HB, Smith TJ, J Biol Chem. 2007 Sep 14;282(37):27468-77. Epub 2007 Jul 11. PMID:17626019

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