2pv6

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{{STRUCTURE_2pv6| PDB=2pv6 | SCENE= }}
{{STRUCTURE_2pv6| PDB=2pv6 | SCENE= }}
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'''HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle'''
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===HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle===
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==Overview==
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Although rarely elicited during natural human infection, the most broadly neutralizing antibodies (BNAbs) against diverse human immunodeficiency virus (HIV)-1 strains target the membrane-proximal ectodomain region (MPER) of viral gp41. To gain insight into MPER antigenicity, immunogenicity, and viral function, we studied its structure in the lipid environment by a combination of nuclear magnetic resonance (NMR), electron paramagnetic resonance (EPR), and surface plasmon resonance (SPR) techniques. The analyses revealed a tilted N-terminal alpha helix (aa 664-672) connected via a short hinge to a flat C-terminal helical segment (675-683). This metastable L-shaped structure is immersed in viral membrane and, therefore, less accessible to immune attack. Nonetheless, the 4E10 BNAb extracts buried W672 and F673 after initial encounter with the surface-embedded MPER. The data suggest how BNAbs may perturb tryptophan residue-associated viral fusion involving the mobile N-terminal MPER segment and, given conservation of MPER sequences in HIV-1, HIV-2, and SIV, have important implications for structure-guided vaccine design.
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{{ABSTRACT_PUBMED_18191596}}
==About this Structure==
==About this Structure==
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2PV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PV6 OCA].
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2PV6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PV6 OCA].
==Reference==
==Reference==
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[[Category: Kinked helix]]
[[Category: Kinked helix]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 13:51:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:59:58 2008''

Revision as of 17:59, 27 July 2008

Image:2pv6.png

Template:STRUCTURE 2pv6

HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle

Template:ABSTRACT PUBMED 18191596

About this Structure

2PV6 is a Single protein structure of sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA.

Reference

HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane., Sun ZY, Oh KJ, Kim M, Yu J, Brusic V, Song L, Qiao Z, Wang JH, Wagner G, Reinherz EL, Immunity. 2008 Jan;28(1):52-63. PMID:18191596

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