2pxg

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{{STRUCTURE_2pxg| PDB=2pxg | SCENE= }}
{{STRUCTURE_2pxg| PDB=2pxg | SCENE= }}
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'''NMR Solution Structure of OmlA'''
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===NMR Solution Structure of OmlA===
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==Overview==
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The outer membrane lipoprotein A (OmlA) belongs to a family of bacterial small lipoproteins widely distributed across the beta and gamma proteobacteria. Although the role of numerous bacterial lipoproteins is known, the biological function of OmlA remains elusive. We found that in the citrus canker pathogen, Xanthomonas axonopodis pv. citri (X. citri), OmlA is coregulated with the ferric uptake regulator (Fur) and their expression is enhanced when X. citri is grown on citrus leaves, suggesting that these proteins are involved in plant-pathogen interaction. To gain insights into the function of OmlA, its conformational and dynamic features were determined by nuclear magnetic resonance. The protein has highly flexible N- and C- termini and a structurally well defined core composed of three beta-strands and two small alpha-helices, which pack against each other forming a two-layer alpha/beta scaffold. This protein fold resembles the domains of the beta-lactamase inhibitory protein BLIP, involved in protein-protein binding. In conclusion, the structure of OmlA does suggest that this protein may be implicated in protein-protein interactions required during X. citri infection. Proteins 2008. (c) 2008 Wiley-Liss, Inc.
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{{ABSTRACT_PUBMED_18186471}}
==About this Structure==
==About this Structure==
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2PXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_axonopodis_pv._citri Xanthomonas axonopodis pv. citri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXG OCA].
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2PXG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_axonopodis_pv._citri Xanthomonas axonopodis pv. citri]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PXG OCA].
==Reference==
==Reference==
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[[Category: Two layer alpha/beta plait]]
[[Category: Two layer alpha/beta plait]]
[[Category: Two layer sandwich architecture]]
[[Category: Two layer sandwich architecture]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:10:00 2008''

Revision as of 08:10, 28 July 2008

Image:2pxg.png

Template:STRUCTURE 2pxg

NMR Solution Structure of OmlA

Template:ABSTRACT PUBMED 18186471

About this Structure

2PXG is a Single protein structure of sequence from Xanthomonas axonopodis pv. citri. Full experimental information is available from OCA.

Reference

The solution structure of the outer membrane lipoprotein OmlA from Xanthomonas axonopodis pv. citri reveals a protein fold implicated in protein-protein interaction., Vanini MM, Spisni A, Sforca ML, Pertinhez TA, Benedetti CE, Proteins. 2008 Jan 10;. PMID:18186471

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