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2py2

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{{STRUCTURE_2py2| PDB=2py2 | SCENE= }}
{{STRUCTURE_2py2| PDB=2py2 | SCENE= }}
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'''Structure of Herring Type II Antifreeze Protein'''
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===Structure of Herring Type II Antifreeze Protein===
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==Overview==
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In order to survive under extremely cold environments, many organisms produce antifreeze proteins (AFPs). AFPs inhibit the growth of ice crystals and protect organisms from freezing damage. Fish AFPs can be classified into five distinct types based on their structures. Here we report the structure of herring AFP (hAFP), a Ca(2+)-dependent fish type II AFP. It exhibits a fold similar to the C-type (Ca(2+)-dependent) lectins with unique ice-binding features. The 1.7 A crystal structure of hAFP with bound Ca(2+) and site-directed mutagenesis reveal an ice-binding site consisting of Thr96, Thr98 and Ca(2+)-coordinating residues Asp94 and Glu99, which initiate hAFP adsorption onto the [10-10] prism plane of the ice lattice. The hAFP-ice interaction is further strengthened by the bound Ca(2+) through the coordination with a water molecule of the ice lattice. This Ca(2+)-coordinated ice-binding mechanism is distinct from previously proposed mechanisms for other AFPs. However, phylogenetic analysis suggests that all type II AFPs evolved from the common ancestor and developed different ice-binding modes. We clarify the evolutionary relationship of type II AFPs to sugar-binding lectins.
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{{ABSTRACT_PUBMED_17579720}}
==About this Structure==
==About this Structure==
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[[Category: Sivaraman, J.]]
[[Category: Sivaraman, J.]]
[[Category: Type ii antifreeze protein]]
[[Category: Type ii antifreeze protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:00:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:32:06 2008''

Revision as of 23:32, 27 July 2008

Image:2py2.png

Template:STRUCTURE 2py2

Structure of Herring Type II Antifreeze Protein

Template:ABSTRACT PUBMED 17579720

About this Structure

2PY2 is a Single protein structure of sequence from Clupea harengus. Full crystallographic information is available from OCA.

Reference

Structure and evolutionary origin of Ca2+-dependent herring type II antifreeze protein., Liu Y, Li Z, Lin Q, Kosinski J, Seetharaman J, Bujnicki JM, Sivaraman J, Hew CL, PLoS ONE. 2007 Jun 20;2(6):e548. PMID:17579720

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