2q1j

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[[Image:2q1j.jpg|left|200px]]
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{{STRUCTURE_2q1j| PDB=2q1j | SCENE= }}
{{STRUCTURE_2q1j| PDB=2q1j | SCENE= }}
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'''The discovery of glycine and related amino acid-based factor xa inhibitors'''
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===The discovery of glycine and related amino acid-based factor xa inhibitors===
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==Overview==
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Herein, we report on the identification of three potent glycine and related amino acid-based series of FXa inhibitors containing a neutral P1 chlorophenyl pharmacophore. A X-ray crystal structure has shown that constrained glycine derivatives with optimized N-substitution can greatly increase hydrophobic interactions in the FXa active site. Also, the substitution of a pyridone ring for a phenylsulfone ring in the P4 sidechain resulted in an inhibitor with enhanced oral bioavailability.
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The line below this paragraph, {{ABSTRACT_PUBMED_16529937}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16529937 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16529937}}
==About this Structure==
==About this Structure==
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[[Category: Serine protease]]
[[Category: Serine protease]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:10:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:45:10 2008''

Revision as of 10:45, 27 July 2008

Image:2q1j.png

Template:STRUCTURE 2q1j

The discovery of glycine and related amino acid-based factor xa inhibitors

Template:ABSTRACT PUBMED 16529937

About this Structure

2Q1J is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The discovery of glycine and related amino acid-based factor Xa inhibitors., Kohrt JT, Filipski KJ, Cody WL, Bigge CF, La F, Welch K, Dahring T, Bryant JW, Leonard D, Bolton G, Narasimhan L, Zhang E, Peterson JT, Haarer S, Sahasrabudhe V, Janiczek N, Desiraju S, Hena M, Fiakpui C, Saraswat N, Sharma R, Sun S, Maiti SN, Leadley R, Edmunds JJ, Bioorg Med Chem. 2006 Jul 1;14(13):4379-92. Epub 2006 Mar 10. PMID:16529937

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