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2q2k

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{{STRUCTURE_2q2k| PDB=2q2k | SCENE= }}
{{STRUCTURE_2q2k| PDB=2q2k | SCENE= }}
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'''Structure of nucleic-acid binding protein'''
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===Structure of nucleic-acid binding protein===
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==Overview==
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The stable inheritance of genetic material depends on accurate DNA partition. Plasmids serve as tractable model systems to study DNA segregation because they require only a DNA centromere, a centromere-binding protein and a force-generating ATPase. The centromeres of partition (par) systems typically consist of a tandem arrangement of direct repeats. The best-characterized par system contains a centromere-binding protein called ParR and an ATPase called ParM. In the first step of segregation, multiple ParR proteins interact with the centromere repeats to form a large nucleoprotein complex of unknown structure called the segrosome, which binds ParM filaments. pSK41 ParR binds a centromere consisting of multiple 20-base-pair (bp) tandem repeats to mediate both transcription autoregulation and segregation. Here we report the structure of the pSK41 segrosome revealed in the crystal structure of a ParR-DNA complex. In the crystals, the 20-mer tandem repeats stack pseudo-continuously to generate the full-length centromere with the ribbon-helix-helix (RHH) fold of ParR binding successive DNA repeats as dimer-of-dimers. Remarkably, the dimer-of-dimers assemble in a continuous protein super-helical array, wrapping the DNA about its positive convex surface to form a large segrosome with an open, solenoid-shaped structure, suggesting a mechanism for ParM capture and subsequent plasmid segregation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18097417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18097417}}
==About this Structure==
==About this Structure==
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[[Category: Protein-dna]]
[[Category: Protein-dna]]
[[Category: Segregation]]
[[Category: Segregation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:12:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:51:47 2008''

Revision as of 00:51, 28 July 2008

Image:2q2k.png

Template:STRUCTURE 2q2k

Structure of nucleic-acid binding protein

Template:ABSTRACT PUBMED 18097417

About this Structure

2Q2K is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Segrosome structure revealed by a complex of ParR with centromere DNA., Schumacher MA, Glover TC, Brzoska AJ, Jensen SO, Dunham TD, Skurray RA, Firth N, Nature. 2007 Dec 20;450(7173):1268-71. PMID:18097417

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