2q3k

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{{STRUCTURE_2q3k| PDB=2q3k | SCENE= }}
{{STRUCTURE_2q3k| PDB=2q3k | SCENE= }}
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'''Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease'''
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===Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease===
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==Overview==
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Human immunodeficiency virus type 1 (HIV-1) protease has been continuously evolving and developing resistance to all of the protease inhibitors. This requires the development of new inhibitors that bind to the protease in a novel fashion. Most of the inhibitors that are on the market are peptidomimetics, where a conserved water molecule mediates hydrogen bonding interactions between the inhibitors and the flaps of the protease. Recently a new class of inhibitors, lysine sulfonamides, was developed to combat the resistant variants of HIV protease. Here we report the crystal structure of a lysine sulfonamide. This inhibitor binds to the active site of HIV-1 protease in a novel manner, displacing the conserved water and making extensive hydrogen bonds with every region of the active site.
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(as it appears on PubMed at http://www.pubmed.gov), where 17596316 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17596316}}
==About this Structure==
==About this Structure==
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[[Category: Protease inhibitor]]
[[Category: Protease inhibitor]]
[[Category: Viral protein]]
[[Category: Viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:15:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:57:45 2008''

Revision as of 20:57, 27 July 2008

Image:2q3k.png

Template:STRUCTURE 2q3k

Crystal Structure of Lysine Sulfonamide Inhibitor Reveals the Displacement of the Conserved Flap Water Molecule in HIV-1 Protease

Template:ABSTRACT PUBMED 17596316

About this Structure

2Q3K is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease., Nalam MN, Peeters A, Jonckers TH, Dierynck I, Schiffer CA, J Virol. 2007 Sep;81(17):9512-8. Epub 2007 Jun 27. PMID:17596316

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