2q6j

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2q6j.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2q6j.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2q6j| PDB=2q6j | SCENE= }}
{{STRUCTURE_2q6j| PDB=2q6j | SCENE= }}
-
'''Crystal Structure of Estrogen Receptor alpha Complexed to a B-N Substituted Ligand'''
+
===Crystal Structure of Estrogen Receptor alpha Complexed to a B-N Substituted Ligand===
-
==Overview==
+
<!--
-
To increase the chemical diversity of bioactive molecules by incorporating unusual elements, we have examined the replacement of a C=C double bond with the isoelectronic, isostructural B-N bond in the context of nonsteroidal estrogen receptor (ER) ligands. While the B-N bond was hydrolytically labile in the unhindered cyclofenil system, the more hindered anilino dimesitylboranes, analogs of triarylethylene estrogens, were easily prepared, hydrolytically stable, and demonstrated substantial affinity for ERs. X-ray analysis of one ERalpha-ligand complex revealed steric clashes with the para methyl groups distorting the receptor; removal of these groups resulted in an increase in affinity, potency, and transcriptional efficacy. These studies define the structural determinants of stability and cellular bioactivity of a B-N for C=C substitution in nonsteroidal estrogens and provide a framework for further exploration of "elemental isomerism" for diversification of drug-like molecules.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17584613}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17584613 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17584613}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Zhou, H.]]
[[Category: Zhou, H.]]
[[Category: Protein-ligand complex]]
[[Category: Protein-ligand complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:26:39 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 23:46:41 2008''

Revision as of 20:46, 28 July 2008

Image:2q6j.png

Template:STRUCTURE 2q6j

Crystal Structure of Estrogen Receptor alpha Complexed to a B-N Substituted Ligand

Template:ABSTRACT PUBMED 17584613

About this Structure

2Q6J is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.

Reference

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands., Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA, Chem Biol. 2007 Jun;14(6):659-69. PMID:17584613

Page seeded by OCA on Mon Jul 28 23:46:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2q6j"
Personal tools