We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2q70

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2q70.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2q70.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2q70| PDB=2q70 | SCENE= }}
{{STRUCTURE_2q70| PDB=2q70 | SCENE= }}
-
'''Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand'''
+
===Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand===
-
==Overview==
+
<!--
-
Benzopyrans are selective estrogen receptor (ER) beta agonists (SERBAs), which bind the ER subtypes alpha and beta in opposite orientations. Here we describe the syntheses of cyclopentanone and cyclohexanone intermediates for SAR studies of the C-ring on the benzopyran scaffold. Modification of the C-ring disrupts binding to ERalpha, thus improving ERbeta selectivity up to 100-fold. X-ray cocrystal structures confirm previously observed binding modes.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17614275}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17614275 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17614275}}
==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Estrogen receptor]]
[[Category: Estrogen receptor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:27:35 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:14:59 2008''

Revision as of 06:15, 28 July 2008

Image:2q70.png

Template:STRUCTURE 2q70

Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand

Template:ABSTRACT PUBMED 17614275

About this Structure

2Q70 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification., Richardson TI, Dodge JA, Durst GL, Pfeifer LA, Shah J, Wang Y, Durbin JD, Krishnan V, Norman BH, Bioorg Med Chem Lett. 2007 Sep 1;17(17):4824-8. Epub 2007 Jun 20. PMID:17614275

Page seeded by OCA on Mon Jul 28 09:14:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2q70"
Personal tools