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2q7o

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[[Image:2q7o.jpg|left|200px]]
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{{STRUCTURE_2q7o| PDB=2q7o | SCENE= }}
{{STRUCTURE_2q7o| PDB=2q7o | SCENE= }}
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'''Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H'''
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===Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H===
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==Overview==
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Human purine nucleoside phosphorylase (PNP) was crystallized with transition-state analogue inhibitors Immucillin-H and DADMe-Immucillin-H synthesized with ribosyl mimics of l-stereochemistry. The inhibitors demonstrate that major driving forces for tight binding of these analogues are the leaving group interaction and the cationic mimicry of the transition state, even though large geometric changes occur with d-Immucillins and l-Immucillins bound to human PNP.
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(as it appears on PubMed at http://www.pubmed.gov), where 18154341 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18154341}}
==About this Structure==
==About this Structure==
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[[Category: Purine nucleoside phosphorylase]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:29:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:56:58 2008''

Revision as of 16:57, 28 July 2008

Image:2q7o.png

Template:STRUCTURE 2q7o

Structure of human purine nucleoside phosphorylase in complex with L-Immucillin-H

Template:ABSTRACT PUBMED 18154341

About this Structure

2Q7O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase., Rinaldo-Matthis A, Murkin AS, Ramagopal UA, Clinch K, Mee SP, Evans GB, Tyler PC, Furneaux RH, Almo SC, Schramm VL, J Am Chem Soc. 2008 Jan 23;130(3):842-4. Epub 2007 Dec 23. PMID:18154341

Page seeded by OCA on Mon Jul 28 19:56:58 2008

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