2q7y

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{{STRUCTURE_2q7y| PDB=2q7y | SCENE= }}
{{STRUCTURE_2q7y| PDB=2q7y | SCENE= }}
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'''Structure of the endogenous iNKT cell ligand iGb3 bound to mCD1d'''
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===Structure of the endogenous iNKT cell ligand iGb3 bound to mCD1d===
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==Overview==
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The semi-invariant Valpha14Jalpha18 T cell receptor (TCR) is expressed by regulatory NKT cells and has the unique ability to recognize chemically diverse ligands presented by CD1d. The crystal structure of CD1d complexed to a natural, endogenous ligand, isoglobotrihexosylceramide (iGb3), illustrates the extent of this diversity when compared to the binding of potent, exogenous ligands, such as alpha-galactosylceramide (alpha-GalCer). A single mode of recognition for these two classes of ligands would then appear problematic for a single T cell receptor. However, the Valpha14 TCR adopts two different conformations in the crystal where, in one configuration, the presence of a larger cavity between the two CDR3 regions could accommodate iGb3 and, in the other, a smaller cavity fits alpha-GalCer more snugly. Alternatively, the extended iGb3 headgroup could be "squashed" upon docking of the TCR and accommodated between the CD1 and TCR surfaces. Thus, the same TCR may adopt alternative modes of recognition for these foreign and self-ligands for NKT cell activation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18295796 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18295796}}
==About this Structure==
==About this Structure==
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[[Category: Mhc fold]]
[[Category: Mhc fold]]
[[Category: Nkt cell]]
[[Category: Nkt cell]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:29:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:00:24 2008''

Revision as of 00:00, 29 July 2008

Image:2q7y.png

Template:STRUCTURE 2q7y

Structure of the endogenous iNKT cell ligand iGb3 bound to mCD1d

Template:ABSTRACT PUBMED 18295796

About this Structure

2Q7Y is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids., Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L, J Mol Biol. 2008 Apr 4;377(4):1104-16. Epub 2008 Jan 31. PMID:18295796

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