1z3g
From Proteopedia
(New page: 200px<br /> <applet load="1z3g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z3g, resolution 3.3Å" /> '''Crystal structure of...) |
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| - | [[Image:1z3g.gif|left|200px]]<br /> | + | [[Image:1z3g.gif|left|200px]]<br /><applet load="1z3g" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1z3g" size=" | + | |
caption="1z3g, resolution 3.3Å" /> | caption="1z3g, resolution 3.3Å" /> | ||
'''Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8'''<br /> | '''Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8'''<br /> | ||
==Overview== | ==Overview== | ||
| - | P25 and P28 proteins are essential for Plasmodium parasites to infect | + | P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle. |
==About this Structure== | ==About this Structure== | ||
| - | 1Z3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http:// | + | 1Z3G is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Plasmodium_vivax Plasmodium vivax]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3G OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Plasmodium vivax]] | [[Category: Plasmodium vivax]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| - | [[Category: Garboczi, D | + | [[Category: Garboczi, D N.]] |
| - | [[Category: Klein, M | + | [[Category: Klein, M M.]] |
| - | [[Category: Long, C | + | [[Category: Long, C A.]] |
| - | [[Category: Saul, A | + | [[Category: Saul, A J.]] |
| - | [[Category: Saxena, A | + | [[Category: Saxena, A K.]] |
[[Category: Singh, K.]] | [[Category: Singh, K.]] | ||
| - | [[Category: Stowers, A | + | [[Category: Stowers, A W.]] |
| - | [[Category: Su, H | + | [[Category: Su, H P.]] |
[[Category: 2a8 fab]] | [[Category: 2a8 fab]] | ||
[[Category: pvs25]] | [[Category: pvs25]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:43 2008'' |
Revision as of 14:11, 21 February 2008
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Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8
Overview
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
About this Structure
1Z3G is a Single protein structure of sequence from Mus musculus and Plasmodium vivax. Full crystallographic information is available from OCA.
Reference
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807
Page seeded by OCA on Thu Feb 21 16:11:43 2008
Categories: Mus musculus | Plasmodium vivax | Single protein | Garboczi, D N. | Klein, M M. | Long, C A. | Saul, A J. | Saxena, A K. | Singh, K. | Stowers, A W. | Su, H P. | 2a8 fab | Pvs25
