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2qcx

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{{STRUCTURE_2qcx| PDB=2qcx | SCENE= }}
{{STRUCTURE_2qcx| PDB=2qcx | SCENE= }}
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'''Crystal structure of Bacillus subtilis TenA Y112F mutant complexed with formyl aminomethyl pyrimidine'''
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===Crystal structure of Bacillus subtilis TenA Y112F mutant complexed with formyl aminomethyl pyrimidine===
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==Overview==
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TenA catalyzes the hydrolysis of 4-amino-5-aminomethyl-2-methylpyrimidine and participates in the salvage of base-degraded thiamin. Here, we describe mutagenesis of the active site of TenA guided by structures of the enzyme complexed to a substrate analog and to the product. Catalytic roles for each of the active site residues are identified and a mechanism for the reaction is described.
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{{ABSTRACT_PUBMED_18054064}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:44:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:00:18 2008''

Revision as of 11:00, 27 July 2008

Template:STRUCTURE 2qcx

Crystal structure of Bacillus subtilis TenA Y112F mutant complexed with formyl aminomethyl pyrimidine

Template:ABSTRACT PUBMED 18054064

About this Structure

2QCX is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis., Jenkins AL, Zhang Y, Ealick SE, Begley TP, Bioorg Chem. 2008 Feb;36(1):29-32. Epub 2007 Dec 3. PMID:18054064

Page seeded by OCA on Sun Jul 27 14:00:18 2008

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