2qhm

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[[Image:2qhm.jpg|left|200px]]
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{{STRUCTURE_2qhm| PDB=2qhm | SCENE= }}
{{STRUCTURE_2qhm| PDB=2qhm | SCENE= }}
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'''crystal structure of Chek1 in complex with inhibitor 2a'''
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===crystal structure of Chek1 in complex with inhibitor 2a===
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==Overview==
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The development of 2,5-dihydro-4H-pyrazolo[4,3-c]quinolin-4-ones as inhibitors of Chk1 kinase is described. Introduction of a fused ring at the C7/C8 positions of the pyrazoloquinolinone provided an increase in potency while guidance from overlapping inhibitor bound Chk1 X-ray crystal structures contributed to the discovery of a potent and solubilizing propyl amine moiety in compound 52 (Chk1 IC(50)=3.1 nM).
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(as it appears on PubMed at http://www.pubmed.gov), where 17804227 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17804227}}
==About this Structure==
==About this Structure==
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[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 14:58:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:42:10 2008''

Revision as of 00:42, 28 July 2008

Image:2qhm.png

Template:STRUCTURE 2qhm

crystal structure of Chek1 in complex with inhibitor 2a

Template:ABSTRACT PUBMED 17804227

About this Structure

2QHM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors., Brnardic EJ, Garbaccio RM, Fraley ME, Tasber ES, Steen JT, Arrington KL, Dudkin VY, Hartman GD, Stirdivant SM, Drakas BA, Rickert K, Walsh ES, Hamilton K, Buser CA, Hardwick J, Tao W, Beck SC, Mao X, Lobell RB, Sepp-Lorenzino L, Yan Y, Ikuta M, Munshi SK, Kuo LC, Kreatsoulas C, Bioorg Med Chem Lett. 2007 Nov 1;17(21):5989-94. Epub 2007 Aug 19. PMID:17804227

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