2qiu

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[[Image:2qiu.jpg|left|200px]]
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{{Seed}}
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[[Image:2qiu.png|left|200px]]
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{{STRUCTURE_2qiu| PDB=2qiu | SCENE= }}
{{STRUCTURE_2qiu| PDB=2qiu | SCENE= }}
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'''Structure of Human Arg-Insulin'''
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===Structure of Human Arg-Insulin===
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==Overview==
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The N-terminal glycine of the A-chain in insulin is reported to be one of the residues that binds to the insulin receptor. Modifications near this region lead to variations in the biological activity of insulin. One such modification viz., an addition of an arginine at the N-terminal A-chain, was reported to possess two-thirds the activity of native insulin. The crystal structure of 2 zinc human arg (A0) insulin has been elucidated to 2A resolution to understand the mechanism of reduction in insulin activity. A conformational transition from T6 to T3R3(f) and a decrease in the surface accessibility of residues in the so called receptor binding region have been observed. The presence of arginine has also induced distortions in the A chain N-terminal helix. The subtle conformational alterations like decrease in surface accessibility, alterations in the charge surface and changes in the relative orientation of the two helices in the A chain may be responsible for the reduction in activity.
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The line below this paragraph, {{ABSTRACT_PUBMED_18029081}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18029081 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18029081}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin., Sreekanth R, Pattabhi V, Rajan SS, Biochimie. 2008 Mar;90(3):467-73. Epub 2007 Sep 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18029081 18029081]
Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin., Sreekanth R, Pattabhi V, Rajan SS, Biochimie. 2008 Mar;90(3):467-73. Epub 2007 Sep 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18029081 18029081]
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Structure of insulin in 4-zinc insulin., Bentley G, Dodson E, Dodson G, Hodgkin D, Mercola D, Nature. 1976 May 13;261(5556):166-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/1272390 1272390]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Hormone]]
[[Category: Hormone]]
[[Category: T3r3 conformation]]
[[Category: T3r3 conformation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:02:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:09:44 2008''

Revision as of 08:09, 29 July 2008

Image:2qiu.png

Template:STRUCTURE 2qiu

Structure of Human Arg-Insulin

Template:ABSTRACT PUBMED 18029081

About this Structure

2QIU is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural interpretation of reduced insulin activity as seen in the crystal structure of human Arg-insulin., Sreekanth R, Pattabhi V, Rajan SS, Biochimie. 2008 Mar;90(3):467-73. Epub 2007 Sep 22. PMID:18029081

Structure of insulin in 4-zinc insulin., Bentley G, Dodson E, Dodson G, Hodgkin D, Mercola D, Nature. 1976 May 13;261(5556):166-8. PMID:1272390

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