2qks

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2qks.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2qks.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2qks| PDB=2qks | SCENE= }}
{{STRUCTURE_2qks| PDB=2qks | SCENE= }}
-
'''Crystal structure of a Kir3.1-prokaryotic Kir channel chimera'''
+
===Crystal structure of a Kir3.1-prokaryotic Kir channel chimera===
-
==Overview==
+
<!--
-
The Kir3.1 K(+) channel participates in heart rate control and neuronal excitability through G-protein and lipid signaling pathways. Expression in Escherichia coli has been achieved by replacing three fourths of the transmembrane pore with the pore of a prokaryotic Kir channel, leaving the cytoplasmic pore and membrane interfacial regions of Kir3.1 origin. Two structures were determined at 2.2 A. The selectivity filter is identical to the Streptomyces lividans K(+) channel within error of measurement (r.m.s.d.&lt;0.2 A), suggesting that K(+) selectivity requires extreme conservation of three-dimensional structure. Multiple K(+) ions reside within the pore and help to explain voltage-dependent Mg(2+) and polyamine blockade and strong rectification. Two constrictions, at the inner helix bundle and at the apex of the cytoplasmic pore, may function as gates: in one structure the apex is open and in the other, it is closed. Gating of the apex is mediated by rigid-body movements of the cytoplasmic pore subunits. Phosphatidylinositol 4,5-biphosphate-interacting residues suggest a possible mechanism by which the signaling lipid regulates the cytoplasmic pore.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17703190}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17703190 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17703190}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Potassium channel]]
[[Category: Potassium channel]]
[[Category: Selectivity filter]]
[[Category: Selectivity filter]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:08:01 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:55:06 2008''

Revision as of 03:55, 28 July 2008

Image:2qks.png

Template:STRUCTURE 2qks

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera

Template:ABSTRACT PUBMED 17703190

About this Structure

2QKS is a Single protein structure of sequence from Mus musculus, burkholderia xenovornas. Full crystallographic information is available from OCA.

Reference

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera., Nishida M, Cadene M, Chait BT, MacKinnon R, EMBO J. 2007 Sep 5;26(17):4005-15. Epub 2007 Aug 16. PMID:17703190

Page seeded by OCA on Mon Jul 28 06:55:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2qks"
Personal tools