2qlr

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{{STRUCTURE_2qlr| PDB=2qlr | SCENE= }}
{{STRUCTURE_2qlr| PDB=2qlr | SCENE= }}
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'''Crystal structure of human kynurenine aminotransferase II'''
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===Crystal structure of human kynurenine aminotransferase II===
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==Overview==
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Human kynurenine aminotransferase II (hKAT-II) efficiently catalyzes the transamination of knunrenine to kynurenic acid (KYNA). KYNA is the only known endogenous antagonist of N-methyl-d-aspartate (NMDA) receptors and is also an antagonist of 7-nicotinic acetylcholine receptors. Abnormal concentrations of brain KYNA have been implicated in the pathogenesis and development of several neurological and psychiatric diseases in humans. Consequently, enzymes involved in the production of brain KYNA have been considered potential regulatory targets. In this article, we report a 2.16A crystal structure of hKAT-II and a 1.95A structure of its complex with kynurenine. The protein architecture of hKAT-II reveals that it belongs to the fold-type I pyridoxal 5-phosphate (PLP)-dependent enzymes. In comparison with all subclasses of fold-type I-PLP-dependent enzymes, we propose that hKAT-II represents a novel subclass in the fold-type I enzymes because of the unique folding of its first 65 N-terminal residues. This study provides a molecular basis for future effort in maintaining physiological concentrations of KYNA through molecular and biochemical regulation of hKAT-II.
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(as it appears on PubMed at http://www.pubmed.gov), where 18056995 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18056995}}
==About this Structure==
==About this Structure==
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[[Category: Pyridoxal phosphate]]
[[Category: Pyridoxal phosphate]]
[[Category: Transit peptide]]
[[Category: Transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:10:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:47:42 2008''

Revision as of 01:47, 28 July 2008

Image:2qlr.png

Template:STRUCTURE 2qlr

Crystal structure of human kynurenine aminotransferase II

Template:ABSTRACT PUBMED 18056995

About this Structure

2QLR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal Structure of Human Kynurenine Aminotransferase II., Han Q, Robinson H, Li J, J Biol Chem. 2008 Feb 8;283(6):3567-73. Epub 2007 Dec 5. PMID:18056995

Page seeded by OCA on Mon Jul 28 04:47:42 2008

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