2qmg

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[[Image:2qmg.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2qmg| PDB=2qmg | SCENE= }}
{{STRUCTURE_2qmg| PDB=2qmg | SCENE= }}
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'''Structure of BACE Bound to SCH745966'''
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===Structure of BACE Bound to SCH745966===
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==Overview==
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Based on a lead compound identified from the patent literature, we developed patentably novel BACE-1 inhibitors by introducing a cyclic amine scaffold as embodied by 1a and 1b. Extensive SAR studies assessed a variety of isophthalamide replacements including substituted pyrrolidinones and ultimately led to the identification of 11. Due to its favorable overall profile, 11 has been extensively profiled in various in vivo settings.
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The line below this paragraph, {{ABSTRACT_PUBMED_17980584}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17980584 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17980584}}
==About this Structure==
==About this Structure==
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:12:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:36:09 2008''

Revision as of 11:36, 28 July 2008

Image:2qmg.png

Template:STRUCTURE 2qmg

Structure of BACE Bound to SCH745966

Template:ABSTRACT PUBMED 17980584

About this Structure

2QMG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of an orally efficaceous 4-phenoxypyrrolidine-based BACE-1 inhibitor., Iserloh U, Pan J, Stamford AW, Kennedy ME, Zhang Q, Zhang L, Parker EM, McHugh NA, Favreau L, Strickland C, Voigt J, Bioorg Med Chem Lett. 2008 Jan 1;18(1):418-22. Epub 2007 Oct 18. PMID:17980584

Page seeded by OCA on Mon Jul 28 14:36:09 2008

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