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2qmr

From Proteopedia

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[[Image:2qmr.gif|left|200px]]
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{{STRUCTURE_2qmr| PDB=2qmr | SCENE= }}
{{STRUCTURE_2qmr| PDB=2qmr | SCENE= }}
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'''Karyopherin beta2/transportin'''
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===Karyopherin beta2/transportin===
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==Overview==
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Karyopherinbeta2 (Kap beta2) or transportin imports numerous RNA binding proteins into the nucleus. Kap beta2 binds substrates in the cytoplasm and targets them through the nuclear pore complex, where RanGTP dissociates them in the nucleus. Here we report the 3.0 A crystal structure of unliganded Kap beta2, which consists of a superhelix of 20 HEAT repeats. Together with previously reported structures of NLS and Ran complexes, this structure provides understanding of conformational heterogeneity that accompanies ligand binding. The Kap beta2 superhelix is divided into three major segments. Two of them (HEAT repeats 9-13 and 14-18), which constitute the substrate binding site, are rigid elements that rotate relative to each other about a flexible hinge. The third (HEAT repeats 1-8), which constitutes the Ran binding site, exhibits conformational changes throughout its length. An analogous segmental architecture is also observed in Importin beta, suggesting that it is functionally significant and may be conserved in other import karyopherins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17997969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17997969}}
==About this Structure==
==About this Structure==
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[[Category: Transport]]
[[Category: Transport]]
[[Category: Transport protein]]
[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:13:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:18:09 2008''

Revision as of 12:18, 27 July 2008

Image:2qmr.png

Template:STRUCTURE 2qmr

Karyopherin beta2/transportin

Template:ABSTRACT PUBMED 17997969

About this Structure

2QMR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational heterogeneity of karyopherin beta2 is segmental., Cansizoglu AE, Chook YM, Structure. 2007 Nov;15(11):1431-41. PMID:17997969

Page seeded by OCA on Sun Jul 27 15:18:09 2008

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