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2qo8

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[[Image:2qo8.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2qo8| PDB=2qo8 | SCENE= }}
{{STRUCTURE_2qo8| PDB=2qo8 | SCENE= }}
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'''Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor'''
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===Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor===
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==Overview==
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Indanesulfonamides are interesting lead compounds for designing selective inhibitors of the different isoforms of the zinc enzyme Carbonic Anhydrase (CA). Herein, we report for the first time the X-ray crystal structure of two such derivatives, namely indane-5-sulfonamide and indane-2-valproylamido-5-sulfonamide, in complex with the physiologically dominant human isoform II. The structural analysis reveals that, although these two inhibitors have quite similar chemical structures, the arrangement of their indane ring within the enzyme active site is significantly diverse. Thus, our findings suggest that the introduction of bulky substituents on the indane-sulfonamide ring may alter the binding mode of this potent class of CA inhibitors, although retaining good inhibitory properties. Accordingly, the introduction of bulky tail moieties on the indane-sulfonamide scaffold may represent a powerful strategy to induce a desired physicochemical property to an aromatic sulfonamide or to obtain inhibitors with diverse inhibition profiles and selectivity for various mammalian CAs.
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The line below this paragraph, {{ABSTRACT_PUBMED_18161740}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18161740 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18161740}}
==About this Structure==
==About this Structure==
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[[Category: Carbonic anhydrase ii]]
[[Category: Carbonic anhydrase ii]]
[[Category: Lyase]]
[[Category: Lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:17:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:15:27 2008''

Revision as of 16:15, 28 July 2008

Image:2qo8.png

Template:STRUCTURE 2qo8

Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor

Template:ABSTRACT PUBMED 18161740

About this Structure

2QO8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic Anhydrase Inhibitors: Binding of Indanesulfonamides to the Human Isoform II., D'Ambrosio K, Masereel B, Thiry A, Scozzafava A, Supuran CT, De Simone G, ChemMedChem. 2007 Dec 27;. PMID:18161740

Page seeded by OCA on Mon Jul 28 19:15:27 2008

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