2qom

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{{STRUCTURE_2qom| PDB=2qom | SCENE= }}
{{STRUCTURE_2qom| PDB=2qom | SCENE= }}
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'''The crystal structure of the E.coli EspP autotransporter Beta-domain.'''
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===The crystal structure of the E.coli EspP autotransporter Beta-domain.===
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==Overview==
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Autotransporters are virulence factors produced by Gram-negative bacteria. They consist of two domains, an N-terminal 'passenger' domain and a C-terminal beta-domain. beta-domains form beta-barrel structures in the outer membrane while passenger domains are translocated into the extracellular space. In some autotransporters, the two domains are separated by proteolytic cleavage. Using X-ray crystallography, we solved the 2.7-A structure of the post-cleavage state of the beta-domain of EspP, an autotransporter produced by Escherichia coli strain O157:H7. The structure consists of a 12-stranded beta-barrel with the passenger domain-beta-domain cleavage junction located inside the barrel pore, approximately midway between the extracellular and periplasmic surfaces of the outer membrane. The structure reveals an unprecedented intra-barrel cleavage mechanism and suggests that two conformational changes occur in the beta-domain after cleavage, one conferring increased stability on the beta-domain and another restricting access to the barrel pore.
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(as it appears on PubMed at http://www.pubmed.gov), where 17994105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17994105}}
==About this Structure==
==About this Structure==
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[[Category: Virulence]]
[[Category: Virulence]]
[[Category: Zymogen]]
[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:19:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:07:06 2008''

Revision as of 07:07, 28 July 2008

Image:2qom.png

Template:STRUCTURE 2qom

The crystal structure of the E.coli EspP autotransporter Beta-domain.

Template:ABSTRACT PUBMED 17994105

About this Structure

2QOM is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Autotransporter structure reveals intra-barrel cleavage followed by conformational changes., Barnard TJ, Dautin N, Lukacik P, Bernstein HD, Buchanan SK, Nat Struct Mol Biol. 2007 Dec;14(12):1214-20. Epub 2007 Nov 11. PMID:17994105

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