2qop

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{{STRUCTURE_2qop| PDB=2qop | SCENE= }}
{{STRUCTURE_2qop| PDB=2qop | SCENE= }}
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'''Crystal structure of the transcriptional regulator AcrR from Escherichia coli'''
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===Crystal structure of the transcriptional regulator AcrR from Escherichia coli===
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==Overview==
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The AcrAB multidrug efflux pump, which belongs to the resistance nodulation division (RND) family, recognizes and extrudes a wide range of antibiotics and chemotherapeutic agents and causes the intrinsic antibiotic resistance in Escherichia coli. The expression of AcrAB is controlled by the transcriptional regulator AcrR, whose open reading frame is located 141 bp upstream of the acrAB operon. To understand the structural basis of AcrR regulation, we have determined the crystal structure of AcrR to 2.55-A resolution, revealing a dimeric two-domain molecule with an entirely helical architecture similar to members of the TetR family of transcriptional regulators. Each monomer of AcrR forms a multientrance pocket of 350 A(3) in the ligand-binding domain. The ligand-binding pocket is surrounded with mostly hydrophobic residues. In addition, a completely buried negatively charged glutamate, expected to be critical for drug binding, is located at the center of the binding pocket. The crystal structure provides novel insight into the mechanisms of ligand binding and AcrR regulation.
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(as it appears on PubMed at http://www.pubmed.gov), where 17950313 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17950313}}
==About this Structure==
==About this Structure==
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[[Category: Transcription]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:14:40 2008''

Revision as of 03:14, 28 July 2008

Image:2qop.png

Template:STRUCTURE 2qop

Crystal structure of the transcriptional regulator AcrR from Escherichia coli

Template:ABSTRACT PUBMED 17950313

About this Structure

2QOP is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the transcriptional regulator AcrR from Escherichia coli., Li M, Gu R, Su CC, Routh MD, Harris KC, Jewell ES, McDermott G, Yu EW, J Mol Biol. 2007 Nov 30;374(3):591-603. Epub 2007 Sep 29. PMID:17950313

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