2qow

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[[Image:2qow.gif|left|200px]]
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{{STRUCTURE_2qow| PDB=2qow | SCENE= }}
{{STRUCTURE_2qow| PDB=2qow | SCENE= }}
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'''Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin. This file contains the 30S subunit of the second 70S ribosome, with spectinomycin bound. The entire crystal structure contains two 70S ribosomes.'''
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===Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin. This file contains the 30S subunit of the second 70S ribosome, with spectinomycin bound. The entire crystal structure contains two 70S ribosomes.===
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==Overview==
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The widely used antibiotic spectinomycin inhibits bacterial protein synthesis by blocking translocation of messenger RNA and transfer RNAs on the ribosome. Here, we show that in crystals of the Escherichia coli 70S ribosome spectinomycin binding traps a distinct swiveling state of the head domain of the small ribosomal subunit. Spectinomycin also alters the rate and completeness of reverse translocation in vitro. These structural and biochemical data indicate that in solution spectinomycin sterically blocks swiveling of the head domain of the small ribosomal subunit and thereby disrupts the translocation cycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 17696316 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17696316}}
==About this Structure==
==About this Structure==
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[[Category: Translation regulation]]
[[Category: Translation regulation]]
[[Category: Trna-binding]]
[[Category: Trna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:20:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:54:21 2008''

Revision as of 15:54, 28 July 2008

Image:2qow.png

Template:STRUCTURE 2qow

Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin. This file contains the 30S subunit of the second 70S ribosome, with spectinomycin bound. The entire crystal structure contains two 70S ribosomes.

Template:ABSTRACT PUBMED 17696316

About this Structure

2QOW is a Protein complex structure of sequences from Escherichia coli and Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

A steric block in translation caused by the antibiotic spectinomycin., Borovinskaya MA, Shoji S, Holton JM, Fredrick K, Cate JH, ACS Chem Biol. 2007 Aug 17;2(8):545-52. Epub 2007 Aug 10. PMID:17696316

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