2qpl

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{{STRUCTURE_2qpl| PDB=2qpl | SCENE= }}
{{STRUCTURE_2qpl| PDB=2qpl | SCENE= }}
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'''Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue'''
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===Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue===
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==Overview==
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The combined use of a rapid virtual screen of a small fragment library together with a single point enzyme assay has been used for the discovery of novel PNP inhibitors. The availability of readily soakable crystals of bovine PNP has allowed the approach to be experimentally validated by determining the crystal structure of one of the inhibitor-PNP complexes. Comparison of the experimentally determined binding mode with that predicted by the virtual screening shows them to be similar. This represents a starting point for the growth of the ligand into a higher affinity inhibitor.
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(as it appears on PubMed at http://www.pubmed.gov), where 17927987 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17927987}}
==About this Structure==
==About this Structure==
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[[Category: Purine nucleoside phosphorylase]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Transferase]]
[[Category: Transferase]]
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Revision as of 21:43, 27 July 2008

Image:2qpl.png

Template:STRUCTURE 2qpl

Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue

Template:ABSTRACT PUBMED 17927987

About this Structure

2QPL is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of calf spleen purine nucleoside phosphorylase complexed to a novel purine analogue., Pereira HM, Berdini V, Cleasby A, Garratt RC, FEBS Lett. 2007 Oct 30;581(26):5082-6. Epub 2007 Oct 2. PMID:17927987

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