2qr8

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[[Image:2qr8.jpg|left|200px]]
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{{STRUCTURE_2qr8| PDB=2qr8 | SCENE= }}
{{STRUCTURE_2qr8| PDB=2qr8 | SCENE= }}
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'''2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)'''
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===2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)===
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==Overview==
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The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18084304 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084304}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:28:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:53:52 2008''

Revision as of 06:53, 29 July 2008

Image:2qr8.png

Template:STRUCTURE 2qr8

2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)

Template:ABSTRACT PUBMED 18084304

About this Structure

2QR8 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304

Page seeded by OCA on Tue Jul 29 09:53:52 2008

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