2qrd

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{{STRUCTURE_2qrd| PDB=2qrd | SCENE= }}
{{STRUCTURE_2qrd| PDB=2qrd | SCENE= }}
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'''Crystal Structure of the Adenylate Sensor from AMP-activated Protein Kinase in complex with ADP and ATP'''
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===Crystal Structure of the Adenylate Sensor from AMP-activated Protein Kinase in complex with ADP and ATP===
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==Overview==
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The AMP-activated protein kinase (AMPK), a sensor of cellular energy status found in all eukaryotes, responds to changes in intracellular adenosine nucleotide levels resulting from metabolic stresses. Here we describe crystal structures of a heterotrimeric regulatory core fragment from Schizosaccharomyces pombe AMPK in complex with ADP, ADP/AMP, ADP/ATP, and 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranotide (AICAR phosphate, or ZMP), a well-characterized AMPK activator. Prior crystallographic studies had revealed a single site in the gamma subunit that binds either ATP or AMP within Bateman domain B. Here we show that ZMP binds at this site, mimicking the binding of AMP. An analogous site in Bateman domain A selectively accommodates ADP, which binds in a distinct manner that also involves direct ligation to elements from the beta subunit. These observations suggest a possible role for ADP in regulating AMPK response to changes in cellular energy status.
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{{ABSTRACT_PUBMED_17937917}}
==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:28:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:53:10 2008''

Revision as of 12:53, 29 July 2008

Image:2qrd.png

Template:STRUCTURE 2qrd

Crystal Structure of the Adenylate Sensor from AMP-activated Protein Kinase in complex with ADP and ATP

Template:ABSTRACT PUBMED 17937917

About this Structure

2QRD is a Protein complex structure of sequences from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structural insight into AMPK regulation: ADP comes into play., Jin X, Townley R, Shapiro L, Structure. 2007 Oct;15(10):1285-95. PMID:17937917

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