2qri

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{{STRUCTURE_2qri| PDB=2qri | SCENE= }}
{{STRUCTURE_2qri| PDB=2qri | SCENE= }}
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'''Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.'''
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===Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.===
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==Overview==
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MHC class I peptide complexes (pMHC) are routinely used to enumerate T cell populations and are currently being evaluated as vaccines to tumors and specific pathogens. Herein, we describe the structures of three generations of single-chain pMHC progressively designed for the optimal presentation of covalently associated epitopes. Our ultimate design employs a versatile disulfide trap between an invariant MHC residue and a short C-terminal peptide extension. This general strategy is nondisruptive of native pMHC conformation and T cell receptor engagement. Indeed, cell-surface-expressed MHC complexes with disulfide-trapped epitopes are refractory to peptide exchange, suggesting they will make safe and effective vaccines. Furthermore, we find that disulfide-trap stabilized, recombinant pMHC reagents reliably detect polyclonal CD8 T cell populations as proficiently as conventional reagents and are thus well suited to monitor or modulate immune responses during pathogenesis.
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The line below this paragraph, {{ABSTRACT_PUBMED_17719490}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17719490 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17719490}}
==About this Structure==
==About this Structure==
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[[Category: Single chain mhc-i]]
[[Category: Single chain mhc-i]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:29:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:54:54 2008''

Revision as of 03:54, 29 July 2008

Image:2qri.png

Template:STRUCTURE 2qri

Crystal structure of a single chain trimer composed of the MHC I heavy chain H-2Kb WT, beta-2microglobulin, and ovalbumin-derived peptide.

Template:ABSTRACT PUBMED 17719490

About this Structure

2QRI is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural engineering of pMHC reagents for T cell vaccines and diagnostics., Mitaksov V, Truscott SM, Lybarger L, Connolly JM, Hansen TH, Fremont DH, Chem Biol. 2007 Aug;14(8):909-22. PMID:17719490

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