2qrn

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{{STRUCTURE_2qrn| PDB=2qrn | SCENE= }}
{{STRUCTURE_2qrn| PDB=2qrn | SCENE= }}
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'''Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex'''
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===Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex===
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==Overview==
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Human deoxycytidine kinase (dCK) is involved in the nucleotide-biosynthesis salvage pathway and has also been shown to phosphorylate several antitumor and antiviral prodrugs. The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex. Here, the structures of dCK complexes with the products dCMP, UDP and Mg2+ ion, and with dAMP, UDP and Mg2+ ion are reported. Structural comparisons show that the product complexes with UDP and a dead-end complex with substrate and UDP have similar active-site conformations.
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(as it appears on PubMed at http://www.pubmed.gov), where 18084067 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18084067}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
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[[Category: Uridine diphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:37:01 2008''

Revision as of 06:37, 29 July 2008

Image:2qrn.png

Template:STRUCTURE 2qrn

Human Deoxycytidine kinase dCMP, UDP, Mg ion product complex

Template:ABSTRACT PUBMED 18084067

About this Structure

2QRN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of human deoxycytidine kinase product complexes., Soriano EV, Clark VC, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2007 Dec;63(Pt 12):1201-7. Epub 2007, Nov 16. PMID:18084067

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