2qsg

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[[Image:2qsg.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2qsg| PDB=2qsg | SCENE= }}
{{STRUCTURE_2qsg| PDB=2qsg | SCENE= }}
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'''Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA'''
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===Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA===
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==Overview==
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Mutations in the nucleotide excision repair (NER) pathway can cause the xeroderma pigmentosum skin cancer predisposition syndrome. NER lesions are limited to one DNA strand, but otherwise they are chemically and structurally diverse, being caused by a wide variety of genotoxic chemicals and ultraviolet radiation. The xeroderma pigmentosum C (XPC) protein has a central role in initiating global-genome NER by recognizing the lesion and recruiting downstream factors. Here we present the crystal structure of the yeast XPC orthologue Rad4 bound to DNA containing a cyclobutane pyrimidine dimer (CPD) lesion. The structure shows that Rad4 inserts a beta-hairpin through the DNA duplex, causing the two damaged base pairs to flip out of the double helix. The expelled nucleotides of the undamaged strand are recognized by Rad4, whereas the two CPD-linked nucleotides become disordered. These findings indicate that the lesions recognized by Rad4/XPC thermodynamically destabilize the Watson-Crick double helix in a manner that facilitates the flipping-out of two base pairs.
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The line below this paragraph, {{ABSTRACT_PUBMED_17882165}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17882165 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17882165}}
==About this Structure==
==About this Structure==
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[[Category: Ultraviolet uv damage]]
[[Category: Ultraviolet uv damage]]
[[Category: Xeroderma pigmentosum]]
[[Category: Xeroderma pigmentosum]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:35:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:59:31 2008''

Revision as of 08:59, 29 July 2008

Image:2qsg.png

Template:STRUCTURE 2qsg

Crystal structure of Rad4-Rad23 bound to a UV-damaged DNA

Template:ABSTRACT PUBMED 17882165

About this Structure

2QSG is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Recognition of DNA damage by the Rad4 nucleotide excision repair protein., Min JH, Pavletich NP, Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165

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