2qts

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{{STRUCTURE_2qts| PDB=2qts | SCENE= }}
{{STRUCTURE_2qts| PDB=2qts | SCENE= }}
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'''Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH'''
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===Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH===
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==Overview==
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Acid-sensing ion channels (ASICs) are voltage-independent, proton-activated receptors that belong to the epithelial sodium channel/degenerin family of ion channels and are implicated in perception of pain, ischaemic stroke, mechanosensation, learning and memory. Here we report the low-pH crystal structure of a chicken ASIC1 deletion mutant at 1.9 A resolution. Each subunit of the chalice-shaped homotrimer is composed of short amino and carboxy termini, two transmembrane helices, a bound chloride ion and a disulphide-rich, multidomain extracellular region enriched in acidic residues and carboxyl-carboxylate pairs within 3 A, suggesting that at least one carboxyl group bears a proton. Electrophysiological studies on aspartate-to-asparagine mutants confirm that these carboxyl-carboxylate pairs participate in proton sensing. Between the acidic residues and the transmembrane pore lies a disulphide-rich 'thumb' domain poised to couple the binding of protons to the opening of the ion channel, thus demonstrating that proton activation involves long-range conformational changes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17882215 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17882215}}
==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Trimer]]
[[Category: Trimer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 15:40:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:47:49 2008''

Revision as of 17:47, 27 July 2008

Image:2qts.png

Template:STRUCTURE 2qts

Structure of an acid-sensing ion channel 1 at 1.9 A resolution and low pH

Template:ABSTRACT PUBMED 17882215

About this Structure

2QTS is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH., Jasti J, Furukawa H, Gonzales EB, Gouaux E, Nature. 2007 Sep 20;449(7160):316-23. PMID:17882215

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