2viu
From Proteopedia
(New page: 200px<br /> <applet load="2viu" size="450" color="white" frame="true" align="right" spinBox="true" caption="2viu, resolution 2.5Å" /> '''INFLUENZA VIRUS HEMA...) |
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| - | [[Image:2viu.gif|left|200px]]<br /> | + | [[Image:2viu.gif|left|200px]]<br /><applet load="2viu" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2viu" size=" | + | |
caption="2viu, resolution 2.5Å" /> | caption="2viu, resolution 2.5Å" /> | ||
'''INFLUENZA VIRUS HEMAGGLUTININ'''<br /> | '''INFLUENZA VIRUS HEMAGGLUTININ'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The structure of the hemagglutinin (HA) of a mutant influenza virus that | + | The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies. |
==About this Structure== | ==About this Structure== | ||
| - | 2VIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 2VIU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VIU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Gigant, B.]] | [[Category: Gigant, B.]] | ||
[[Category: Knossow, M.]] | [[Category: Knossow, M.]] | ||
| - | [[Category: Skehel, J | + | [[Category: Skehel, J J.]] |
| - | [[Category: Wharton, S | + | [[Category: Wharton, S A.]] |
[[Category: NAG]] | [[Category: NAG]] | ||
[[Category: envelope protein]] | [[Category: envelope protein]] | ||
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[[Category: hemagglutinin]] | [[Category: hemagglutinin]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:56:16 2008'' |
Revision as of 16:56, 21 February 2008
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INFLUENZA VIRUS HEMAGGLUTININ
Overview
The structure of the hemagglutinin (HA) of a mutant influenza virus that escapes neutralization by a monoclonal antibody shows that the mutation causes changes in HA structure which avoid an energetically less favorable conformation. However, the structure of the mutant HA.Fab complex indicates that the antibody binds selectively to mutant HA in a wild type-like distorted conformation. The association of an antibody with a less favored HA conformation represents an alternative to previously described mechanisms of escape from neutralization by antibodies.
About this Structure
2VIU is a Single protein structure of sequence from Unidentified influenza virus with as ligand. Full crystallographic information is available from OCA.
Reference
Antigen distortion allows influenza virus to escape neutralization., Fleury D, Wharton SA, Skehel JJ, Knossow M, Bizebard T, Nat Struct Biol. 1998 Feb;5(2):119-23. PMID:9461077
Page seeded by OCA on Thu Feb 21 18:56:16 2008
